What types of evidence indicate that cancer arises from genetic changes?Discuss how is cancer different from most other types of genetic diseases?
Outline Knudson’s multistage theory of cancer and describe how it helps to explain unilateral and bilateral cases of retinoblastoma.
What is haploinsufficiency? How might it affect cancer risk?
What role do telomeres and telomerase play in cancer progression?
Explain how chromosome deletions, inversions, and translations may cause cancer.
What is genomic instability? Give some ways in which genomic instability may
arise.
How is an epigenetic change different from a mutation?
How is DNA methylation related to cancer?
What is a Mendelian population? How is the gene pool of a Mendelian population usually described?
What are the predictions given by the Hardy Weinberg law?
What is random mating?
:Define inbreeding and briefly describe its effects on a population.
Define inbreeding and briefly describe its effects on a population.
What determines the allelic frequencies at mutational equilibrium?