Poly cystic Ovary Syndrome Paper

Polycystic ovary (or ovarian) syndrome (PCOS) at the beginning was described in 1935. (Stein, and Leventhal., 1935). As far as the discovery of polycystic ovaries is concerned it was found at least a century before its description in 1935.( Vallisneri et al., 1721; Chereau 1844; Rokitanski 1855). It affects 6% to 8% of women around the globe, using the National Institutes of Health (NIH) 1990 criteria (Knochenhauer et al., 1998 ; Diamanti-Kandarakis et al., 1999 ; Michelmore et al., 1999; Asuncion et al., 2000; Aziz et al., 2004).Poly cystic Ovary Syndrome Paper

PCOs can be considered one of the most common disorders of humans, and the single most common endocrine abnormality of women of reproductive age. Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women that affects both reproductive and metabolic function (Franks 1995). Its diagnosis is based on the presence of at least two of the following criteria:

Hyperandrogenism,which is determined by the presence of total testosterone (TT) or free testosterone (FT) excess or hirsutism.
Ovarian dysfunction (OD), this is characterized by oligo-amenorrhea and chronic anovulation.
The detection of a specific polycystic ovarian morphology (PCOm) (presence of cysts). Poly cystic Ovary Syndrome Paper
All disorders which are caused by the excess of androgen should be eliminated (Zawadski and Dunaif., 1992; Azziz et al., 2009). There is both scientific and clinical evidence that PCOS may be characterized by a list of dysmetabolic features, chiefly insulin resistance and compensatory hyperinsulinemia, glucose intolerance states, lipid abnormalities and low-grade inflammation (Conway et al., 2014). Excess body weight and obesity are associated with PCOS and this worsen the hormonal and metabolic features of PCOS and may, possibly, reduce the responsiveness to the most common therapeutic strategies extensively used around the globe.