Hypertension And Risk Of Cardiovascular Disease

The hypertension and the Cardiovascular disease are the factors which affects several organ-systems of our body, and this get initiated with the rheological properties of blood and its formed elements. Red blood cells (RBCs) are moving in circulation are continuously exposed to the Reactive oxygen species (ROS) that are co-transported and circulating within the vascular system. Also RBC membranes are specifically vulnerable to this oxidative stress. In the current study, we investigate morphological and electrochemical characteristics of RBCs obtained from the patients using scanning electron microscopy (SEM), microscopy and Zeta potential. Statistical analyses of data showed that Hypertensive and cardiac patients RBCs possessed significantly reduced zeta potential relative to that of RBCs from healthy individuals (P-value < 0. 0001). SEM imaging of Hypertensive RBCs revealed increased anisocytes and poikilocytes. These parameters were found exacerbated in patients suffering from cardiac blockage. This increased membrane deformability impairs the RBC’s capacity to adequately adapt its shape to navigate blood vessels, especially microvasculature, and this decrease is also reflected in the cell’s morphology. Changes to morphology and deformability may also indicate the oxidative degradation of polyunsaturated fatty acids in the membrane resulting in the significantly lowered ZP values of hypertensive patients than the healthy volunteers. These findings suggest that hypertension has impact on the RBC and its membrane integrity with potential for exacerbating pathological cellular function, hemorheology. Hence, it can be concluded that ZP can be used as an effective diagnostic tool for the detection of hypertension and cardio-vascular disorder risk.Hypertension And Risk Of Cardiovascular Disease