How do 3 HPV-encoded proteins work synergistically to promote the proliferation of HPV-16 infected cells?

HPV-16 is the primary causative agent of cervical cancer and is increasingly implicated in many orop Show more HPV-16 is the primary causative agent of cervical cancer and is increasingly implicated in many oropharyngeal cancers. How do 3 HPV-encoded proteins work synergistically to promote the proliferation of HPV-16 infected cells? A. E5 mimics PDGF; E6 ubiquitinates Rb causing its degradation; E7 binds p53 and prevents its binding to the p21 CIP gene. B. E5 mimics PDGF; E6 ubiquitinates p53 causing its degradation; E7 binds cyclin D/CDK and activates it. C. E5 mimics PDGF; E6 ubiquitinates p53 causing its degradation; E7 binds Rb and prevents its binding to E2F. D. E5 truncates the EGF receptor converting it to the ErbB oncoprotein; E6 ubiquitinates p53 causing its degradation; E7 binds Rb and prevents its binding to E2F. E. E5 truncates the EGF receptor converting it to the ErbB oncoprotein; E6 phosphorylates p53 inactivating it; E7 binds E2F and inhibits its activity.