Discuss the mechanisms that Bordetella pertussis,Streptococcus pneumoniae,Corynebacterium diphtheriae andMycobacterium tuberculosis utilize to cause disease in the respiratory tract.

You must state what disease these microorganisms cause and what role does transduction play in their disease causing process. In addition, please discuss the host immune defenses the microbes would have to overcome to be successful at causing disease. Also, please discuss what the microbe could contain that would allow them to overcome these host immune responses, and the association between normal flora and respiratory tract infections. Include a discussion what roles personal hygiene, quorum sensing and sequential timing play in microbial respiratory tract diseases. Whats a receptor-mediated process? Whats the significance of SOD and catalase to the pathogenesis ofBordetella pertussis? Whats an obligate aerobe? Whats generalized and specialized transduction and their significance to the pathogenesis ofStreptococcus pneumoniae andCorynebacterium diphtheriae?