Development Of Pillar-Based Dissolving Micro needle

Oral and parenteral injections are among the widely used drug delivery routes. While oral drug delivery is remarkably more patient-friendly compared with injection, it is associated with a number of side effects including vomiting, headache, abdominal pain, diarrhea and nausea. Furthermore, the bioavailability of a large number of drugs is reduced due to first-pass elimination of body. On the other hand, hypodermic injection is advantageous compared with oral delivery as it delivers drugs directly into the blood stream, reducing side effects due to accurate dosage delivery. However, hypodermic injection is also associated with various drawbacks including requirement of expertise to administer an injection, and the potential of infections caused by needle stick waste. Therefore, to solve above mentioned limitations, dissolving microneedles (DMNs) were developed.Development Of Pillar-Based Dissolving Micro needle

DMNs are polymeric micro-sized needles capable of loading drugs within their body and releasing them upon application for systemic or local delivery. This is an interesting transdermal drug delivery platform, as it has proven to be capable of delivering a wide range of drugs including unstable drugs and even vaccines. As DMNs are much smaller than traditional hypodermic needles, they are considered minimally invasive and are less likely to cause pain upon application making them a patient-friendly approach to therapeutic administration. On the other hand, DMNs are mainly places onto patches, which often reduces the delivery efficacy of encapsulated materials because of skin elasticity. In addition, the chemicals in the patch may cause skin irritation. Moreover, it is difficult to adhere patches to flexible body joint areas and to hairy skin. Especially, patients must wait for long time for the DMNs to completely dissolve before the patch can be removed.