Crystallization Process of Paracetamol Behavior

The paper “Crystallization Process of Paracetamol Behaviour” is a great example of a term paper on medical science. A widely used medicine and known as an analgesic and antipyretic, paracetamol is a mild painkiller and decreases the temperature of patients with fever. There are at present more than ninety familiar products containing paracetamol, which are available over the counter from drug stores (Ellis et. al. 2002, p. 3). Paracetamol is acetaminophen and is a practical substitute to aspirin, as analgesics and antipyretics. Different from aspirin, their anti-inflammatory activity is inadequate but they lack many of the side effects of aspirin and so were frequently used.

Paracetamol is comparatively harmless and safe when taken moderately. However, a large amount of paracetamol can cause serious liver damage, which can result in hepatic failure (Koay and Walmsley 1996, p. 350). Paracetamol taken in large amounts is extremely hepatotoxic because of the production of a minor metabolite or ‘ Acetimidoquinone’ (Varcoe 2001 p. 59). For adults, the recommended therapeutic dosage of paracetamol is 0.5-1g every 4-6 hours and must not exceed 4 grams daily. Paracetamol is absorbed somewhat quickly from the gastrointestinal tract and forwarded to the liver where it is metabolized. Crystallization Process of Paracetamol Behavior

It is then delivered to the body’ s tissue through blood circulation. While paracetamol is being metabolized in the liver, several metabolites are created. One of them is ‘ Acetyl-benzo-quinone imine’ , which is an exceedingly reactive and toxic metabolite. However, a protein from the liver called ‘ glutathione’ , which protects the liver from cell damage (Courtenay and Butler 1999, p. 58), usually detoxifies acetyl-benzo-quinone imine. Polymorphic Structures of Some Compound “ A substance capable of existing in more than one crystalline form is said to exhibit polymorphism” (Amiji and Sandman 2002, p. 36).