Assignment: Best Practice for Colorectal Cancer in Women

Assignment: Best Practice for Colorectal Cancer in Women Essay

Colorectal Cancer

Studies such as Mori et al. (2017) reveal that colorectal cancer is the second most frequently occurring cancer in women. The condition denotes a type of cancer whose genesis is traced to the rectum or the colon. Further, the condition begins as a polyp on the internal lining of the colon or rectum. However, while certain polyps can become cancerous after an extended period, not all graduate into that. According to Botteri et al. (2017), pre-cancerous polyps known as Adenomatous polyps (adenomas) are the ones that change into cancer over time. However, for the polyps to become cancerous, they must be larger than 1 cm, more than two, and have dysplasia after their elimination since the former is a pre-cancerous condition. The risk of colorectal cancer appears particularly heightened in post-menopausal women. The reason for the increased risk of colorectal cancer in such women relates to the decreased levels of feminine hormone such as estrogen during this age (Mori et al., 2017). Therefore, the assessment and management of the condition needs to occur via the adoption of current best practices

Current Best Practices for Colorectal Cancer

Haziman, Ravinderan, Thangavelu, and Thomas (2019) posit that hormone replacement therapy such as estrogen-induced signaling leads to the suppression of tumor cells in colorectal cancer. Indeed, the application of hormone replacement therapy has garnered

Assignment Best Practice for Colorectal Cancer in Women Essay
Assignment Best Practice for Colorectal Cancer in Women Essay

worldwide support as one of the best practices in the management of CRC. In this study and others such as Botteri et al. (2017) and Mori et al. (2019), the adoption of HRT in clinical practice has direct correlation with reduction of CRC in post-menopausal women. Moreover, estrogen regulates the KCNQ1/KCNE3 potassium channel for purposes of modulating the body’s secretion of chloride when a woman menstruates. The KCNQ1 additionally acts a tumor suppressor, which is critical in the management of CRC in post-menopausal women. The tumor-suppressing properties of estrogen are thus leveraged by practitioners during the HRT so as to manage CRC.