In its simplest form, the pain circuit in the body can be described as follows: pain stimulates pain receptors, and this stimulus is transferred via specialised nerves to the spinal cord and from there to the brain.
The pain stimulus is processed in the brain, which then sends an impulse down the spinal cord and via appropriate nerves which command the body to react, for instance by withdrawing the hand from a very hot object.Pathophysiology Of Pain Essay Paper
Perception of the pain stimulus: from the pain receptors to the brain
Pain receptors
Pain receptors are present everywhere in the body, especially the skin, surfaces of the joints, periosteum (the specialised lining around the bone), walls of the arteries, and certain structures in the skull. Other organs, such as the gut and muscles, have fewer pain receptors. It is interesting to note that the brain itself does not have any pain receptors at all, and is therefore insensitive to pain.Pathophysiology Of Pain Essay Paper
Pain receptors are free nerve endings. There are three types of pain receptor stimuli: mechanical, thermal and chemical. A mechanical stimulus would be, for example, high pressure or stretching, and a thermal pain stimulus would be extreme heat or cold.
Chemical pain receptors can be stimulated by chemicals from the outside world (e.g. acids), but also by certain products present in the body and released as a result of trauma, inflammation or other painful stimuli. Examples of these substances are bradykinins, serotonin, potassium ions and acids (such as lactic acid, which causes muscle pain after heavy exercise).Pathophysiology Of Pain Essay Paper
Compounds called prostaglandins are released with painful stimuli, and although they don’t directly stimulate pain receptors, they do increase their sensitivity. Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) decrease the effect of prostaglandins, that is why they work as painkillers. Paracetamol operates in the central nervous system and the NSAIDs are peripheral-acting substances.
Pain nerve fibres – fast pain and slow pain
From the pain receptors, the pain stimulus is transmitted through peripheral nerves to the spinal cord and from there to the brain. This happens via two different types of nerve fibre: “fast pain” and “slow pain” fibres.Pathophysiology Of Pain Essay Paper
What is “fast pain” and “slow pain”?
A pain stimulus, e.g. if you cut yourself, consists of two sensations. The first one is the so-called “fast pain” sensation, and is experienced as a sharp pain. After a few seconds, this becomes a sensation of “slow pain”, which is a duller and more of a burning pain. This slow pain normally lasts for a few days or weeks, but if inappropriately processed by the body, it can last for several months and give rise to chronic pain.
Fast pain, like pricking yourself with a needle or touching a burning object, is mainly related to painful stimuli of the skin, mouth and anus.Pathophysiology Of Pain Essay Paper
It is transmitted by relatively thick nerve fibres, although this term is relative because they are still microscopically thin, with a diameter of two- to five-thousandth of a millimetre. These nerves are called A-delta fibres. Because of their relative thickness, they allow the pain stimulus to be transferred very fast (at a speed of 5 to 30 metres per second), hence the name. This allows the body to withdraw immediately from the painful and harmful stimulus in order to avoid further damage.
Fast pain is well localised, meaning that a person can normally describe very accurately where exactly the pain is. The pain is sharp and “cutting”.
The pain does not radiate, i.e. you feel it on a very particular spot. It is difficult to overcome this type of pain, even with strong painkillers. This means that if surgery needs to be performed, the pain of the incision cannot be taken away with strong opioids alone.Pathophysiology Of Pain Essay Paper
However, infiltration of the affected area or the nerve with a local anaesthetic will take away all sensation, including any sharp pain. This is what happens in surgery performed under local anaesthetic.
Slow pain, which starts immediately after the fast pain, is transmitted by very thin nerve fibres called C-nerve fibres (their diameter is between 0.2 and one thousandth of a millimetre). Because of their size, the pain impulse can only be transmitted slowly to the brain, at a speed of less than 2 metres per second. The response of the body is to hold the affected body part immobile (guarding, spasm or rigidity), so that healing can take place.Pathophysiology Of Pain Essay Paper