Smokers such as Mrs. J should benefit from evidence-based guidelines nicotine replacement therapy, bupropion SR, and/or varenicline as an effective alternative for smoking cessation therapy, especially when combined with behavioral interventions. Combination pharmacotherapy is indicated for highly nicotine-dependent smokers like this patient, since Mrs. J has failed with monotherapy for several years. An additional form of nicotine replacement therapy or an addition of a non-nicotine replacement therapy oral medication (bupropion or varenicline) may also be helpful. Thus, rate of successful smoking cessation at 1 year will be about 3% to 5% when the patient simply tries to stop, 7% to 16% if the patient/smoker undergoes behavioral intervention, and up to 24% when receiving pharmacological treatment and behavioral support. Nicotine Replacement Therapy & Hypertension Assignment Papers.