Here we sought to determine the relationship between STAT3 activity and Galectin-3 (Gal-3) and to investigate the cytotoxic effect of PectaSol-C Modified Citrus Pectin (Pect-MCP) as a specific competitive inhibitor of Galectin-3 (Gal-3) in combination with paclitaxel (PTX) to kill ovarian cancer cell multicellular tumor spheroid (MCTS). SKOV-3 cells in 2D and 3D culture were treated with exogenous Gal-3 for assessment of STAT3 activity. Two-way ANOVA main effect and IC50 of each drug Paclitaxel (PTX) and Pect-MCP or in combination were obtained from MTT assay results.Serous Ovarian Cancer (SOC) Assignment